Institute for Diabetes, Obesity, and Metabolism, and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Address correspondence to: Mitchell A. Lazar, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 12-102 Smilow Center for Translational Research, 3400 Civic Center Blvd., Philadelphia, Pennsylvania 19104, USA. Phone: 215.898.0198; Email: firstname.lastname@example.org.
First published May 14, 2018 - More info
See the related article at PPARγ deacetylation dissociates thiazolidinedione’s metabolic benefits from its adverse effects.
Thiazolidinediones (TZDs) are the only antidiabetic drugs that reverse insulin resistance. They have been a valuable asset in the treatment of type 2 diabetes, but their side effects have curtailed widespread use in the clinic. In this issue of the JCI, Kraakman and colleagues provide evidence that deacetylation of the nuclear receptor PPARγ improves the therapeutic index of TZDs. These findings should revitalize the quest to employ insulin sensitization as a first-line approach to managing type 2 diabetes.
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