[HTML][HTML] Oncogenic cooperation between IL7R-JAK-STAT pathway mutations
I Lodewijckx, N Mentens, K Jacobs, J Cools - Hemasphere, 2021 - journals.lww.com
Interleukin-7 (IL7) receptor (IL7R)-mediated signaling through the JAK-STAT pathway is
essential for hematopoiesis, as well as for the survival, proliferation and activity of mature T
and B lymphocytes. 1 The IL7R-JAK-STAT signaling pathway is frequently mutated in T-cell
acute lymphoblastic leukemia (T-ALL), an aggressive hematological malignancy caused by
the accumulation of multiple genetic alterations. 2–5 In about 30% of patients with T-ALL,
constitutive activation of the IL7R-JAK-STAT signaling pathway is the result of activating …
essential for hematopoiesis, as well as for the survival, proliferation and activity of mature T
and B lymphocytes. 1 The IL7R-JAK-STAT signaling pathway is frequently mutated in T-cell
acute lymphoblastic leukemia (T-ALL), an aggressive hematological malignancy caused by
the accumulation of multiple genetic alterations. 2–5 In about 30% of patients with T-ALL,
constitutive activation of the IL7R-JAK-STAT signaling pathway is the result of activating …
