The vascular system is critical for developmental growth, tissue homeostasis and repair but
also for tumor development. Bone morphogenetic protein (BMP) signaling has recently
emerged as a fundamental pathway of the endothelium by regulating cardiovascular and
lymphatic development and by being causative for several vascular dysfunctions. Two
vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial
hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling …