[...] most matrices used in the past only represent snapshots (serum, saliva) or short-term values (24-hour urine) of cortisol levels instead of chronic cortisol levels in the human body. Depending on the cause of the hypercortisolism, lifestyle changes (targeting diet, alcohol use, sleep, stress, pain) and psychological and societal interventions to reduce stress and the stigma of obesity may also reduce cardiometabolic consequences in people with hypercortisolistic obesity.[...] hair cortisol analyses provide a relatively novel way to study the relationships between cortisol and obesity and the cardiometabolic sequelae, now clearly showing that, on average, systemic cortisol levels in people with obesity are elevated.