[HTML][HTML] The mammalian numb phosphotyrosine-binding domain: Characterization of binding specificity and identification of a novel PDZ domain-containing numb …
SE Dho, S Jacob, CD Wolting, MB French… - Journal of Biological …, 1998 - ASBMB
Numb is a phosphotyrosine-binding (PTB) domain-containing protein implicated in the
control of cell fate decisions during development. A modified two-hybrid screen in yeast was
used to identify Numb PTB domain-interacting proteins important for Numb function. Here
we report the identification of a novel protein, LNX, which interacts specifically with the
Numb PTB domain. Two differentially expressed LNX messages encode overlapping
proteins with predicted molecular masses of 80 kDa (LNX) and 70 kDa (LNX-b). LNX and …
control of cell fate decisions during development. A modified two-hybrid screen in yeast was
used to identify Numb PTB domain-interacting proteins important for Numb function. Here
we report the identification of a novel protein, LNX, which interacts specifically with the
Numb PTB domain. Two differentially expressed LNX messages encode overlapping
proteins with predicted molecular masses of 80 kDa (LNX) and 70 kDa (LNX-b). LNX and …