[HTML][HTML] Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4
Z Du, X Tong, X Ye - Journal of Biological Chemistry, 2013 - ASBMB
Cyclin/cyclin-dependent kinases (Cdks) are critical protein kinases in regulating cell cycle
progression. Among them, cyclin D1/Cdk4 exerts its function mainly in the G 1 phase. By
using the tandem affinity purification tag approach, we identified a set of proteins interacting
with Cdk4, including NDR1/2. Interestingly, confirming the interactions between NDR1/2 and
cyclin D1/Cdk4, we observed that NDR1/2 interacted with cyclin D1 independent of Cdk4,
but NDR1/2 and cyclin D1/Cdk4 did not phosphorylate each other. In addition, we found that …
progression. Among them, cyclin D1/Cdk4 exerts its function mainly in the G 1 phase. By
using the tandem affinity purification tag approach, we identified a set of proteins interacting
with Cdk4, including NDR1/2. Interestingly, confirming the interactions between NDR1/2 and
cyclin D1/Cdk4, we observed that NDR1/2 interacted with cyclin D1 independent of Cdk4,
but NDR1/2 and cyclin D1/Cdk4 did not phosphorylate each other. In addition, we found that …
