[HTML][HTML] Characterization of CD28null T cells in idiopathic pulmonary fibrosis
DM Habiel, MS Espindola, C Kitson, AV Azzara… - Mucosal …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease, with unknown etiopathogenesis
and suboptimal therapeutic options. Previous reports have shown that increased T-cell
numbers and CD28 null phenotype is predictive of prognosis in IPF, suggesting that these
cells might have a role in this disease. Flow cytometric analysis of explanted lung cellular
suspensions showed a significant increase in CD8+ CD28 null T cells in IPF relative to
normal lung explants. Transcriptomic analysis of CD3+ T cells isolated from IPF lung …
and suboptimal therapeutic options. Previous reports have shown that increased T-cell
numbers and CD28 null phenotype is predictive of prognosis in IPF, suggesting that these
cells might have a role in this disease. Flow cytometric analysis of explanted lung cellular
suspensions showed a significant increase in CD8+ CD28 null T cells in IPF relative to
normal lung explants. Transcriptomic analysis of CD3+ T cells isolated from IPF lung …
