[HTML][HTML] Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression
R Irons, BA Carlson, DL Hatfield, CD Davis - The Journal of nutrition, 2006 - Elsevier
Selenium has cancer protective effects in a variety of experimental systems. Currently, it is
not known whether selenoproteins or low molecular weight selenocompounds are
responsible for this activity. To evaluate the contribution of selenoproteins to the cancer
protective effects of selenium, we used transgenic mice that carry a mutant selenocysteine
transfer RNA gene, which causes reduced selenoprotein synthesis. Selenium homeostasis
was characterized in liver and colon of wild-type and transgenic mice fed selenium-deficient …
not known whether selenoproteins or low molecular weight selenocompounds are
responsible for this activity. To evaluate the contribution of selenoproteins to the cancer
protective effects of selenium, we used transgenic mice that carry a mutant selenocysteine
transfer RNA gene, which causes reduced selenoprotein synthesis. Selenium homeostasis
was characterized in liver and colon of wild-type and transgenic mice fed selenium-deficient …