The regenerative potential of parietal epithelial cells in adult mice
Previously, we showed that some podocytes in juvenile mice are recruited from cells lining
Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell
population for podocytes. To investigate whether PECs also replenish podocytes in adult
mice, PECs were genetically labeled in an irreversible fashion in 5-week-old mice. No
significant increase in labeled podocytes was observed, even after 18 months. To accelerate
a potential regenerative mechanism, progressive glomerular hypertrophy was induced by …
Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell
population for podocytes. To investigate whether PECs also replenish podocytes in adult
mice, PECs were genetically labeled in an irreversible fashion in 5-week-old mice. No
significant increase in labeled podocytes was observed, even after 18 months. To accelerate
a potential regenerative mechanism, progressive glomerular hypertrophy was induced by …