Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI
O Kocher, M Krieger - Current opinion in lipidology, 2009 - journals.lww.com
O Kocher, M Krieger
Current opinion in lipidology, 2009•journals.lww.comSR-BI mediates several features of HDL metabolism and function, some of which depend on
SR-BI's interaction with PDZK1. Exploration of the structure and function of PDZK1 and the
mechanisms by which it controls SR-BI will provide additional insights into HDL metabolism
and may provide the basis for new therapeutic modalities for cardiovascular disease.
SR-BI's interaction with PDZK1. Exploration of the structure and function of PDZK1 and the
mechanisms by which it controls SR-BI will provide additional insights into HDL metabolism
and may provide the basis for new therapeutic modalities for cardiovascular disease.
Summary
SR-BI mediates several features of HDL metabolism and function, some of which depend on SR-BI's interaction with PDZK1. Exploration of the structure and function of PDZK1 and the mechanisms by which it controls SR-BI will provide additional insights into HDL metabolism and may provide the basis for new therapeutic modalities for cardiovascular disease.
Lippincott Williams & Wilkins