[HTML][HTML] Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein
WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms
tumor. Among its known functions, WTX interacts with the β-transducin repeat containing
family of ubiquitin ligase adaptors and promotes the ubiquitination and degradation of the
transcription factor β-catenin, a key control point in the WNT/β-catenin signaling pathway.
Here, we report that WTX interacts with a second ubiquitin ligase adaptor, KEAP1, which
functions to regulate the ubiquitination of the transcription factor NRF2, a key control point in …
tumor. Among its known functions, WTX interacts with the β-transducin repeat containing
family of ubiquitin ligase adaptors and promotes the ubiquitination and degradation of the
transcription factor β-catenin, a key control point in the WNT/β-catenin signaling pathway.
Here, we report that WTX interacts with a second ubiquitin ligase adaptor, KEAP1, which
functions to regulate the ubiquitination of the transcription factor NRF2, a key control point in …