[HTML][HTML] Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
AR Todeschini, JN Dos Santos, K Handa… - Journal of biological …, 2007 - ASBMB
Glycosphingolipids (GSLs) at the cell surface membrane are associated or complexed with
signal transducers (Src family kinases and small G-proteins), tetraspanins, growth factor
receptors, and integrins. Such organizational framework, defining GSL-modulated or-
dependent cell adhesion, motility, and growth, is termed" glycosynapse"(Hakomori, S., and
Handa, K.(2002) FEBS Lett. 531, 88–92; Hakomori, S.(2004) Ann. Braz. Acad. Sci. 76, 553–
572). We describe here the functional organization of the glycosynaptic microdomain, and …
signal transducers (Src family kinases and small G-proteins), tetraspanins, growth factor
receptors, and integrins. Such organizational framework, defining GSL-modulated or-
dependent cell adhesion, motility, and growth, is termed" glycosynapse"(Hakomori, S., and
Handa, K.(2002) FEBS Lett. 531, 88–92; Hakomori, S.(2004) Ann. Braz. Acad. Sci. 76, 553–
572). We describe here the functional organization of the glycosynaptic microdomain, and …