Epigenetics in cardiac fibrosis: emphasis on inflammation and fibroblast activation
MB Felisbino, TA McKinsey - JACC: Basic to Translational Science, 2018 - jacc.org
JACC: Basic to Translational Science, 2018•jacc.org
Chemical modifications to nucleosomal DNA and histone tails greatly influence transcription
of adjacent and distant genes, a mode of gene regulation referred to as epigenetic control.
Here, the authors summarize recent findings that have illustrated crucial roles for epigenetic
regulatory enzymes and reader proteins in the control of cardiac fibrosis. Particular
emphasis is placed on epigenetic regulation of stress-induced inflammation and fibroblast
activation in the heart. The potential of developing innovative small molecule “epigenetic …
of adjacent and distant genes, a mode of gene regulation referred to as epigenetic control.
Here, the authors summarize recent findings that have illustrated crucial roles for epigenetic
regulatory enzymes and reader proteins in the control of cardiac fibrosis. Particular
emphasis is placed on epigenetic regulation of stress-induced inflammation and fibroblast
activation in the heart. The potential of developing innovative small molecule “epigenetic …
Summary
Chemical modifications to nucleosomal DNA and histone tails greatly influence transcription of adjacent and distant genes, a mode of gene regulation referred to as epigenetic control. Here, the authors summarize recent findings that have illustrated crucial roles for epigenetic regulatory enzymes and reader proteins in the control of cardiac fibrosis. Particular emphasis is placed on epigenetic regulation of stress-induced inflammation and fibroblast activation in the heart. The potential of developing innovative small molecule “epigenetic therapies” to combat cardiac fibrosis is highlighted.
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