Dendritic spine instability in a mouse model of CDKL5 disorder is rescued by insulin-like growth factor 1
G Della Sala, E Putignano, G Chelini, R Melani… - Biological …, 2016 - Elsevier
Background CDKL5 (cyclin-dependent kinase-like 5) is mutated in many severe
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to
interact with synaptic proteins, but an in vivo analysis of the role of CDKL5 in dendritic spine
dynamics and synaptic molecular organization is still lacking. Methods In vivo two-photon
microscopy of the somatosensory cortex of Cdkl5−/y mice was applied to monitor structural
dynamics of dendritic spines. Synaptic function and plasticity were measured using …
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to
interact with synaptic proteins, but an in vivo analysis of the role of CDKL5 in dendritic spine
dynamics and synaptic molecular organization is still lacking. Methods In vivo two-photon
microscopy of the somatosensory cortex of Cdkl5−/y mice was applied to monitor structural
dynamics of dendritic spines. Synaptic function and plasticity were measured using …
