Epilepsy, autism, and neurodevelopment: kindling a shared vulnerability?

KL Gilby, TJ O'Brien - Epilepsy & Behavior, 2013 - Elsevier
Epilepsy and autism spectrum disorder (ASD) share many primary and comorbid symptoms.
The degree of clinical overlap is believed to signify a 'spectrum of vulnerability'that arises out
of an early common dysfunction in central nervous system development. However, research
into the underlying, and potentially shared, etiopathological mechanisms is challenging
given the extensive comorbidity profiles. Adding to the degree of difficulty is the frequently
evolving recompartmentalization of diagnostic criteria within each disorder. This review …