Leukemia inhibitory factor (LIF)
Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of
cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor
complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M,
cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC). Despite common signal
transduction mechanisms (JAK/STAT, MAPK and PI3K) LIF can have paradoxically opposite
effects in different cell types including stimulating or inhibiting each of cell proliferation …
cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor
complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M,
cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC). Despite common signal
transduction mechanisms (JAK/STAT, MAPK and PI3K) LIF can have paradoxically opposite
effects in different cell types including stimulating or inhibiting each of cell proliferation …