Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients
A Zeevi, J Lunz, B Feingold, M Shullo… - The Journal of Heart and …, 2013 - Elsevier
BACKGROUND: Sensitized heart transplant candidates are evaluated for donor-specific anti-
HLA IgG antibody (DSA) by Luminex single-antigen bead (SAB) testing (SAB-IgG) to
determine donor suitability and help predict a positive complement-dependent cytotoxicity
crossmatch (CDC-XM) by virtual crossmatching (VXM). However, SAB testing used for VXM
does not correlate perfectly with CDC-XM results and individual transplant programs have
center-specific permissible thresholds to predict crossmatch positivity. A novel Luminex SAB …
HLA IgG antibody (DSA) by Luminex single-antigen bead (SAB) testing (SAB-IgG) to
determine donor suitability and help predict a positive complement-dependent cytotoxicity
crossmatch (CDC-XM) by virtual crossmatching (VXM). However, SAB testing used for VXM
does not correlate perfectly with CDC-XM results and individual transplant programs have
center-specific permissible thresholds to predict crossmatch positivity. A novel Luminex SAB …