Integral membrane proteins and bilayer proteomics
JP Whitelegge - Analytical chemistry, 2013 - ACS Publications
Analytical chemistry, 2013•ACS Publications
Integral membrane proteins reside within the bilayer membranes that surround cells and
organelles, playing critical roles in movement of molecules across them and the transduction
of energy and signals. While their extreme amphipathicity presents technical challenges,
biological mass spectrometry has been applied to all aspects of membrane protein
chemistry and biology, including analysis of primary, secondary, tertiary, and quaternary
structures as well as the dynamics that accompany functional cycles and catalysis.
organelles, playing critical roles in movement of molecules across them and the transduction
of energy and signals. While their extreme amphipathicity presents technical challenges,
biological mass spectrometry has been applied to all aspects of membrane protein
chemistry and biology, including analysis of primary, secondary, tertiary, and quaternary
structures as well as the dynamics that accompany functional cycles and catalysis.
Integral membrane proteins reside within the bilayer membranes that surround cells and organelles, playing critical roles in movement of molecules across them and the transduction of energy and signals. While their extreme amphipathicity presents technical challenges, biological mass spectrometry has been applied to all aspects of membrane protein chemistry and biology, including analysis of primary, secondary, tertiary, and quaternary structures as well as the dynamics that accompany functional cycles and catalysis.
ACS Publications