Osteonectin, also termed BM40 or SPARC (secreted protein, acidic and rich in cysteine) is a
multifunctional glycoprotein involved in tissue mineralization, cell-extracellular matrix
interactions as well as angiogenesis. It has been suggested that osteonectin may play a key
role in the process of tumoral invasion and metastasis in certain malignancies. In this study,
we reviewed the clinical records and the histopathologic slides of 188 thin cutaneous
malignant melanomas (≤ 0.75 mm). Among them, 12 cases underwent progression and …