From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets
C Eifert, RS Powers - Nature reviews cancer, 2012 - nature.com
C Eifert, RS Powers
Nature reviews cancer, 2012•nature.comThe analysis of human cancer by genome sequencing and various types of arrays has
proved that many tumours harbour hundreds of genes that are mutated or substantially
altered by copy number changes. But how many of these changes are meaningful? And how
can we exploit these massive data sets to yield new targets for cancer treatment? In this
Opinion article, we describe emerging approaches that aim to determine which altered
genes are actually contributing to cancer, as well as their potential as therapeutic targets.
proved that many tumours harbour hundreds of genes that are mutated or substantially
altered by copy number changes. But how many of these changes are meaningful? And how
can we exploit these massive data sets to yield new targets for cancer treatment? In this
Opinion article, we describe emerging approaches that aim to determine which altered
genes are actually contributing to cancer, as well as their potential as therapeutic targets.
Abstract
The analysis of human cancer by genome sequencing and various types of arrays has proved that many tumours harbour hundreds of genes that are mutated or substantially altered by copy number changes. But how many of these changes are meaningful? And how can we exploit these massive data sets to yield new targets for cancer treatment? In this Opinion article, we describe emerging approaches that aim to determine which altered genes are actually contributing to cancer, as well as their potential as therapeutic targets.
nature.com