Evolution of geographic atrophy of the retinal pigment epithelium

JP Sarks, SH Sarks, MC Killingsworth - Eye, 1988 - nature.com
JP Sarks, SH Sarks, MC Killingsworth
Eye, 1988nature.com
The aim of this study was to trace the evolution of geographic atrophy (GA) by clinical
documentation and by clinico-morphological correlation in representative eyes. Geographic
atrophy commonly commenced within a parafoveal band of incipient atrophy of varying
width, characterised by semisolid drusen and a microreticular pigment pattern. Progession
of atrophy mostly skirted fixation and visual acuity was a poor guide to the functional impact,
an estimate of the percentage of fovea involved proving a more useful clinical parameter …
Abstract
The aim of this study was to trace the evolution of geographic atrophy (GA) by clinical documentation and by clinico-morphological correlation in representative eyes. Geographic atrophy commonly commenced within a parafoveal band of incipient atrophy of varying width, characterised by semisolid drusen and a microreticular pigment pattern. Progession of atrophy mostly skirted fixation and visual acuity was a poor guide to the functional impact, an estimate of the percentage of fovea involved proving a more useful clinical parameter. The rate of progression slowed once GA had involved all the retina affected by incipient atrophy and the risk of choroidal neovascularization appeared to decline.
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