5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
Nature neuroscience, 2010•nature.com
Mice lacking 5-HT 2C receptors (5-HT2CRs) displayed hepatic insulin resistance, a
phenotype normalized by re-expression of 5-HT2CRs only in pro-opiomelanocortin (POMC)
neurons. 5-HT2CR deficiency also abolished the anti-diabetic effects of meta-
chlorophenylpiperazine (a 5-HT2CR agonist); these effects were restored when 5-HT2CRs
were re-expressed in POMC neurons. Our findings indicate that 5-HT2CRs expressed by
POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose …
phenotype normalized by re-expression of 5-HT2CRs only in pro-opiomelanocortin (POMC)
neurons. 5-HT2CR deficiency also abolished the anti-diabetic effects of meta-
chlorophenylpiperazine (a 5-HT2CR agonist); these effects were restored when 5-HT2CRs
were re-expressed in POMC neurons. Our findings indicate that 5-HT2CRs expressed by
POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose …
Abstract
Mice lacking 5-HT 2C receptors (5-HT2CRs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT2CRs only in pro-opiomelanocortin (POMC) neurons. 5-HT2CR deficiency also abolished the anti-diabetic effects of meta-chlorophenylpiperazine (a 5-HT2CR agonist); these effects were restored when 5-HT2CRs were re-expressed in POMC neurons. Our findings indicate that 5-HT2CRs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver.
nature.com