HmTAP suppresses and treats EAE transferred with PLP139-151–specific line T cells. Naive SJL/J mice injected intravenously on day 0 with 5 × 105 activated PLP139-151–specific line T cells received a daily intravenous injection (arrows) of approximately 100 μg hmTAP in 500 μl PBS or PBS alone (a) from day 0 (12 hours after the T cell transfer) to day 4 for suppression of EAE, or (b) from day 4 (anticipated day of disease onset) to day 8 for treatment of EAE.